Receptor-G protein coupling is established by a potential conformational switch in the beta gamma complex.
收藏PubMed Central1995-09-26 更新2026-05-02 收录
下载链接：
https://pmc.ncbi.nlm.nih.gov/articles/PMC40932/
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资源简介：
Receptor-G protein interaction is characterized by cycles of association and dissociation. We present evidence which indicates that during receptor-G protein interaction, the C-terminal tail of the G protein gamma subunit, which is masked in the beta gamma complex, is exposed and establishes high-affinity contact with the receptor. This potential conformational switch provides a mechanism to regulate receptor-G protein coupling. This switch may also be significant for the role of the beta gamma complex in regulation of effector function. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1995-09-26
