Inclusion body myositis

Inclusion body myositis (IBM) is a rare muscle degeneration diseases. It is caused by presumably both genetic risk factors and environmental factors stimulated by increasing age. The mechanism of pathogenicity includes inflammation, ER stress/unfolded protein response, and disturbed autophagy, which leads to an accumulation of inclusions. The mechanism is similar to Alzheimer's disease and Parkinson's disease in neurons. This pathway is based on Figure 1 of Askanas V. et al. 2015.

肌内包涵体肌炎（IBM）是一种罕见的肌肉退行性疾病。该病可能由遗传风险因素及随着年龄增长而加剧的环境因素共同引起。其致病机制包括炎症、内质网应激/未折叠蛋白反应以及自噬紊乱，进而导致包涵体的累积。其机制与神经元中的阿尔茨海默病和帕金森病相似。本通路基于 Askanas V. 等人于 2015 年发表的 Figure 1。