RUNX1 promotes colorectal tumor growth and metastasis by regulating CDK8

Unresectable hepatic metastasis of colorectal cancer (CRC) responds poorly to existing therapies and is the leading cause of CRC mortality. Runt-related transcription factors (RUNXs) have recently come to prominence because of their important, at times paradoxical, roles in tumor development. However, the expression status, biological function and underlying mechanism of RUNX1 in human CRC remain unknown. Overall design: ChIP-seq analysis for RUNX1 to identify the genes that are directly regulated by RUNX1 at the transcriptional level