Dataset from A Two Part, Randomized, Open-label, Cross Over Study in Healthy Elderly Participants to Evaluate the Relative Bioavailability of Hydrobromide Salt Tablet Formulations of Danirixin in the Fed and Fasted States, and to Evaluate the Effect of Food and Gastric Acid Secretion Suppression on Danirixin Pharmacokinetics Following Administration of Hydrobromide Salt Tablets

This 2-part study will be carried out on healthy elderly subjects to evaluate relative
bioavailability of danirixin formulations. Part A will support the selection of the
formulation and Part B will assess food effect, bioavailability and pharmacokinetic (PK)
profile of selected formulation from Part A. Danirixin is currently administered with food,
therefore the investigation of food effect for the selected formulation could potentially
enable dosing without food. Approximately 16 subjects will be included in Part A and
approximately 24 subjects will be included in Part B. Both parts will include a screening
phase, treatment phase with in-between washout period and a follow-up phase.