nELAVL HITS-CLIP and RNA-seq in Alzheimer's Disease patients and IMR-32 neuroblastoma cells

NIAID Data Ecosystem2026-03-08 收录

转录后调控

神经退行性分子机制

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA232667 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

创建时间：

2013-12-29

Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration

神经退行性分子机制

TDP-43蛋白功能

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with loss of nuclear TDP-43. Here we identify that TDP-43 regulates expression of the neuronal growth-associated fa

NIAID Data Ecosystem130

Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation

神经发育调控

转录后调控

During Drosophila and vertebrate brain development, the conserved transcription factor Prospero/Prox1 is an important regulator of the transition between proliferation and differentiation. Prospero le

NIAID Data Ecosystem50

Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells.

神经退行性分子机制

蛋白质功能调控

Nuclear factor TDP-43 is known to play an important role in several neurodegenerative pathologies. In general, TDP-43 is an abundant protein within the eukaryotic nucleus that binds to many coding and

NIAID Data Ecosystem20

Genome-wide mRNA targets of CPEB1 in muscle stem cells

转录后调控

肌肉干细胞分子图谱

We performed CPEB1 RIP-seq on freshly isolated muscle stem cells. We found that CPEB1 associated genes are enriched in translational regulation pathways. Overall design: Two biological replicates of C

NIAID Data Ecosystem60

Global gene profiling of (-)-Epigallocatechin-3-gallate (EGCG)-induced neuronal death. Mus musculus

神经退行性分子机制

药物神经保护

Alzheimer’s disease (AD) is the most common form of adult-onset dementia with severe intellectual deterioration and is characterised by the accumulation of the amyloid-β (Aβ) peptides and the presence

NIAID Data Ecosystem30

nELAVL HITS-CLIP and RNA-seq in Alzheimer's Disease patients and IMR-32 neuroblastoma cells

资源简介：

相关数据集