Norepinephrine modulates calcium dynamics in cortical oligodendrocyte precursor cells promoting proliferation during arousal in mice. Norepinephrine modulates calcium dynamics in cortical oligodendrocyte precursor cells promoting proliferation during arousal in mice

Oligodendrocyte precusor cells (OPCs) exhibit near membrane calcium transients that can be enhacned by norepinephrine-mediated activation of alpha1A adrenergic receptors in vivo. In order to determine if norepinephrine directly modulates OPC behaviors, we performed an unbiased, transcriptomic-based assessment of biological processes altered in OPCs after activation of alpha1 adrenergic receptors Overall design: Comparative gene expression profiling analysis of RNA-seq data for primary mouse OPCs (isolated from P4-P7 CD-1 pups, equal sexes) treated with and without phenylephrine (PE, 20 uM for 1 hr)