Integrated transcriptomic analysis of Trichosporon asahii uncovers the core genes and pathways of fluconazole resistance. Integrated transcriptomic analysis of Trichosporon asahii uncovers the core genes and pathways of fluconazole resistance

We performed a series of fluconazole (FLC) perturbation experiments for two T. asahii strains, a clinical isolate stain CBS2479 (T2) and an environmental isolate strain CBS8904 (T8), to uncover potential genes and pathways involved in FLC resistance. Overall design: We treated both types of T. asahii cells with two different doses of FLC for 5 different time points respectively, and then collected RNAs for gene expression profiling.