High-throughput RNA sequencing reveals major alterations of inflammatory molecules involved in pathogenesis of peri- lesional psoriasis after NBUVB treatment. High-throughput RNA sequencing reveals major alterations of inflammatory molecules involved in pathogenesis of peri- lesional psoriasis after NBUVB treatment

We report the high-throughput profiling of tissue biopsy in peri- lesion from psoriasis skin before the start of NB-UVB therapy and after treatment.RNA sequencing (RNA-Seq) was conducted to assay the transcriptomes and identify differentially expressed transcripts enriched in major pathway analysis. Overall design: This study aimed to understand the mechanisms of psoriasis through analyzing differentially expressed genes with RNA-Seq technique by using phototherapy. This research was conducted in patients with moderate to severe plaque-type psoriasis who received NB-UVB treatment.