NOX3 complex:RAC1:GTP generates superoxide from oxygen
收藏reactome.org2025-03-24 收录
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While NOX3:CYBA complex has constitutive NADPH oxidase activity, the presence of NCF1, NCF2 or NOXA1 and RAC1:GTP enhances the production of superoxide O2- by the NOX3:CYBA complex. When NCF1 is replaced with NOXO1, RAC1:GTP becomes dispensible for the full activation of the NOX3 complex (Ueno et al. 2005, Ueyama et al. 2006, Miyano and Sumimoto 2007, Kao et al. 2008)
尽管NOX3:CYBA复合体具有构成性的NADPH氧化酶活性,但NCF1、NCF2或NOXA1以及RAC1:GTP的存在可增强NOX3:CYBA复合体产生超氧阴离子O2-的能力。当NCF1被NOXO1所替代时,RAC1:GTP对于NOX3复合体的完全激活变得非必需(Ueno等,2005年;Ueyama等,2006年;Miyano和Sumimoto,2007年;Kao等,2008年)
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