Echocardiogram measurements at baseline, 10 and 14 weeks after 6-OHDA for each animal.

FS is calculated as [(LVDd – LVDs)/LVDd]×100. Three animals experienced large decreases in FS compared to baseline, but there was no significant change in left ventricle diameter or in anterior and posterior wall thickness. This suggests that the increased luminal dimensions of the left ventricle were not due to the loss of cardiac muscle. AWd, anterior wall thickness in diastole. AWs, anterior wall thickness in systole. PWd, posterior wall thickness in diastole. PWs, posterior wall thickness in systole. LVDd, left ventricle diameter in diastole. LVDs, left ventricle diameter in systole. FS, fractional shortening.