NMR Determinations of the Absolute Configuration of α-Chiral Primary Amines

We have established a methodology to determine the absolute configuration of α-chiral primary amines by derivatization to the corresponding imines with each enantiomer of 2′-methoxy-1,1′-binaphthalene-8-carbaldehyde (1). This methodology proceeds on the basis of modified Mosher’s method, and sufficiently large ΔδRS values can be obtained to elucidate the stereochemistry of the amines.