The composition of the experimental diets modified based on the AIN-93M diet.
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The composition of the experimental diets modified based on the AIN-93M diet.
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2024-12-09
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Seasoning ingredients in a medium fat diet regulate lipid metabolism [hypothalamus]
Despite a variety of seasoning ingredients in diets, little is known about their cooperative effect on animal metabolism. We fed rats a diet containing 30 wt.% instant noodle with a 26% fat-to-energy ratio for 30 days (N-group). Compared with rats that were fed the same diet without seasonings (C-group), the N-group showed lower liver triacylglycerol levels and higher fecal cholesterol levels. To assess the mechanisms underlying this phenotype, we conducted transcriptome analyses of the hypothalamic–pituitary axis (HP), liver and white adipose tissue (WAT). Our results suggest that these ingredients may affect lipid homeostasis via the HP axis. We fed rats a diet containing 30 wt.% instant noodle with a 26% fat-to-energy ratio for 30 days (N-group). For the control group, we used rats that were fed the same diet without seasonings (C-group), and the mRNA expression in the hypothalamus was compared between the two groups.
NIAID Data Ecosystem40
Effect of sourdough bread diet supplementation on the rat gut microbiota
Effect of sourdough bread diet supplementation on the rat gut microbiota
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Digesta passage variables at the terminal ileum of pigs fed control and enzymatically-modified starch (EMS) diets.
Digesta passage variables at the terminal ileum of pigs fed control and enzymatically-modified starch (EMS) diets.
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Table S1 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models
Details of experimental diets
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Plasma levels of β–carotene and lutein.
Plasma samples obtained from participants (n = 14) before (Day 0) and after (Day 28) ingesting young spinach leaves. Data represent means ± standard deviation.
Figshare2023-07-19 更新40
Levels of significantly different lipids in livers of mice fed a high-fat diet supplemented with SM.
Male mice were fed a high-fat (HF) diet without or with 0.6% wt/wt SM (HFSM) for 4 weeks. Liver lipids were quantified as described in “Methods”. Values represent means±SEM. Percentage difference between groups is given in italics. Significant differences between the HF and HFSM groups were determined by Student's t-test:†Pcorrected
Figshare2015-12-02 更新20
Gut microbiome of infants at 3, 6, and 12 months of age, with different dietary interventions. Raw sequence reads. Gut microbiome of infants at 3, 6, and 12 months of age, with different dietary interventions.
We sought to determine how the infant gut microbiota evolve during infancy, in particular in relation to hygiene-related environmental factors, allergic and atopic disorders, and a randomized dietary intervention. Therefore, 288 healthy, exclusively breastfed infants were enrolled in a dietary intervention study from three months of age. 70 were followed up at six and twelve months to study the evolution of their gut microbiota, using 16S ribosomal RNA gene targeted amplicon sequencing.
NIAID Data Ecosystem40
Results from one-way ANOVA of the effects of the experimental diets on intestinal carcinogenesis.
Results from one-way ANOVA of the effects of the experimental diets on intestinal carcinogenesis.
Figshare2017-04-20 更新20
Effects of Baobab fruit powder on gut and cardiometabolic health in obesity-Protocol for a randomised placebo-controlled trial
Despite its commercial availability, its high fibre, vitamin C and polyphenol content, there are limited scientific studies exploring the cardiometabolic effects of Baobab fruit powder (BFP) in humans. Due to its high fibre content, BFP may offer a potential intervention to reduce intestinal barrier dysfunction and therefore mitigate cardiometabolic risk. A randomized, double-blind, placebo-controlled trial will be conducted with 50 apparently healthy participants living with obesity. Participants will consume either 16 g of BFP or an isocaloric placebo daily for 45 days. The primary outcome will be intestinal permeability determined using the urinary lactulose/mannitol test. Secondary outcomes include blood biomarkers in intestinal permeability (lipopolysaccharide (LPS), intestinal fatty acid binding protein (IFABP), soluble cluster of differentiation 14 (sCD14) and LPS-binding protein (LBP)), microbiota diversity and composition and cardiometabolic risk markers including glucose levels, blood lipid profiles and blood pressure. Liver and kidney function will be monitored at baseline, after 2 weeks and following 45 days of consumption as safety outcomes. The study protocol ensures rigorous, weekly monitoring of participant compliance and tolerability, along with careful tracking of potential adverse events. Intention-to-treat analysis and mixed effects models will be employed for statistical analyses. Potential selection bias and participant dropout are addressed through thorough recruitment strategies and predefined sample size calculations. This research will contribute to the growing body of knowledge on dietary interventions in the context of cardiometabolic risk, particularly in populations at risk for developing metabolic disease.
Figshare2026-02-10 更新00
Supplemental Table S7
Liver oxysterol data of the B6/129 mice fed WD with/without coffee
Figshare2022-10-03 更新70
Arctic ground squirrel gut microbial community Raw sequence reads. gut metagenome
Gut microbial communities derived from the cecal content of arctic ground squirrels treated with differing diets: highfat, lowfat, restricted calorie, control, and time zero.
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mouse gut metagenome Transcriptome or Gene expression. mouse gut metagenome
In terms of gut microbiota, the diversity and structure of gut microbiota in both two plant-meat group was better than that in both two red-meat group.
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Additional file 1: of Similarity of the dog and human gut microbiomes in gene content and response to diet
Table S1. Properties of the dogs. (XLSX 15Â kb)
Figshare2018-04-19 更新10
plantMASST - FASST searches results for the diet-related use cases
This deposition contains results of FASST searches conducted for the diet-related studies employed as use cases in the plantMASST manuscript.
Zenodo2026-04-27 更新00
Gut microbiota abundance.
The raw sequence reads of gut microbiota. Group: week 0, 2 and 7 indicates weeks of sucralose consumption; Count, read count; Tax-name: taxonomy name; Tax-rank, ranking of the taxonomic classification, Percentage: relative abundance normalized to all counts in each sample. (XLSX)
NIAID Data Ecosystem40
The effect of Mediterranean diet supplemented with dairy foods on the gut microbiota and cardiovascular health in an Australian population Targeted loci. Homo sapiens
The effect of 8-weeks Mediterranean diet supplemented with dairy foods or 8-weeks low-fat control diet on the faecal microbiome and cardiovascular health in an Australian population
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Main FA composition of phosphatidylethanolamine in the frontal cortex of unstressed or stressed rats fed the CON, ENR or DEF diets1,2.
For each line, values with different letters (a–c) showed significant differences between the three dietary groups in the unstressed condition (ANOVA followed by MCP, p).1Values are means ± SEM (g/100 g TFA; n = 6 per group).2FA, fatty acids; 20:4n-6: arachidonic acid (AA); 22:5n-6: docosapentaenoic acid (DPA); 22:6n-3: docosahexaenoic acid (DHA); DEF, Deficient diet; CON, Control diet; ENR, Enriched diet.
Figshare2015-12-02 更新00
Role of DNA methylation in the dietary restriction mediated cellular memory. Mus musculus
Dietary restriction (DR) appears to create a cellular memory, which persists even after DR is discontinued.DNA methylation seems a logical mechanism by which a cellular memory could be established.we first examined the effect of short-term DR on gene expression and DNA methylation, then determined whether the changes persisted after DR was discontinued and mice returned to ad libitum (AL) feeding.We show that DR can induce substantial changes in gene expression within one month of its implementation in various tissues, and ~15-50% of these changes in gene expression persist even when DR is discontinued. We then determined whether DR induced changes in DNA methylation in the promoter of three candidate genes (Pomc, Hsph1 and Nts1) that were correlated with the changes in the expression of these genes. Overall design: mRNA profiles in 5 tissues (Liver, Epididymal fat, Colon, Hypothalamus, Hippocampus) of mice under three feeding diets (ad libitum (AL), diet restricted, ad libitum after diet restricted)
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Physiological Responses to Different Diets in Intervention Group, including drop-outs (Intent-to-treat) (N = 41).
aBP, blood pressure; CRP, C-reactive protein; HOMA-IR, Homeostatic model assessment-insulin resistance; OGTT, oral glucose tolerance test; PAI-1, plasminogen activator inhibitor-1; % B, endothelium-mediated dilation; % N, non-endothelium-mediated dilation; IL, interleukin; TAD, traditional Asian diet; TNF-α, tumor necrosis factor-alpha; TWD, typical Western diet.bP-value of the changes observed before and after 8 weeks of TAD (Visit 3-Visit 2).cP-value of the changes observed before and after 8 weeks of TWD (Visit 4-Visit 3).dP-value of the Visit 4-Visit 3 and Visit 3-Visit 2.Physiological Responses to Different Diets in Intervention Group, including drop-outs (Intent-to-treat) (N = 41).
Figshare2015-12-02 更新00
