Selection of significant (target gene, lncRNA, RBP) triplets such that the lncRNA-RBP pair forms a statistically significant (Bonferroni corrected p-value < 0.01) interaction term in modeling the target gene’s expression.

Columns A-F indicate the id and name of the target gene, lncRNA and RBP in that order, while column G reports the Bonferroni corrected p-value for the interaction term. Columns H-Q report on the p-value of differential expression of the target genes between two groups of samples defined as: HH = samples with high levels of lncRNA and high levels of RBP; HL = samples with high levels of lncRNA and low levels of RBP; LH = samples with low levels of lncRNA and high levels of RBP; LL = samples with low levels of lncRNA and low levels of RBP. Thus columns labeled as HH-LH report on differential expression (of target gene) between the HH and LH groups, etc. For each contrast, column with label suffixed with “.direction” reports on whether the average gene expression is higher (1) or lower (-1) in the first group compared to the second group; column with label suffixed with “.p” reports the p-value from a T-test between the two groups. The selection of triplets shown here meet the additional criteria that the HH-HL, HH-LH, and HH-LL contrasts are statistically significant (p < 0.05) and have the same direction of differential expression (all 1 or all -1).
(XLSX)