EED in complex with PRC2 allosteric inhibitor compound 7
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EED in complex with PRC2 allosteric inhibitor compound 7 Descriptor: CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... Authors: Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. Deposit date: 2021-12-17 Release date: 2022-04-13 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies. J.Med.Chem., 65, 2022
创建时间：
2021-12-17
