Multimodal mucosal and systemic immune characterization of a non-human primate trachoma model highlights the critical role of local immunity during acute phase disease

Trachoma is a leading cause of infection-related blindness worldwide. This disease is caused by recurrent Chlamydia trachomatis (Ct) infections of the conjunctiva and develops in two phases: i) active (acute trachoma, characterized by follicular conjunctivitis), then long-term: ii) scarring (chronic trachoma, characterized by conjunctival fibrosis, corneal opacification, and eyelid malposition). Scarring trachoma is driven by the number and severity of reinfections. The immune system plays a pivotal role in trachoma including exacerbation of the disease. Hence the immune system may also be key to developing a trachoma vaccine. Therefore, we characterized clinical and local immune response kinetics in a non-human primate model of acute conjunctival Ct infection and disease. The conjunctiva of a non-human primate (NHP, Cynomolgus monkeys - Macaca fascicularis-) was inoculated with Ct (B/Tunis-864 strain, B serovar). Clinical ocular monitoring was performed using a standardized photographi..., , , # Multimodal mucosal and systemic immune characterization of a novel non-human primate trachoma model highlights the critical role of local immunity during acute phase disease

[https://doi.org/10.5061/dryad.69p8cz982](https://doi.org/10.5061/dryad.69p8cz982)

This dataset contains results characterizing our model of trachoma (non-human primate). Those results comprise clinical scoring to assess the clinical signs, bacterial quantification to assess the conjunctival infection by *Chlamydia trachomatis*, as well as local and systemic immune assessment (conjunctival immune population with flow cytometry, immunoglobulin, and cytokines quantifications).

## Description of the data and file structure

Results are organized by type of data, each data type in a different folder.

Clinical scoring is compiled in a single Excel file of clinical scoring results (on a scale of 0 to 8 for total scoring, 0 to 3 for inflammation score, and 0 to 5 for follicles score).

Bacterial loads of conjunctiva...