Estrogen-independent molecular actions of mutant estrogen receptor alpha in endometrial cancer
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2019-09-11
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FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition through its actions as chromatin remodeler [WT41]
FOXA2 encodes a transcription factor mutated in 10% of endometrial cancers (ECs), with a higher mutation rate in aggressive variants. FOXA2 has essential roles in embryonic and uterine development. Ho
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ARID1A and PI3-Kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion [12Z_1A_PI3K_RNA-seq]. ARID1A and PI3-Kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion [12Z_1A_PI3K_RNA-seq]
ARID1A and PI3-Kinase (PI3K) pathway alterations are common in neoplasms originating from the uterine endometrium. Here we show that monoallelic loss of ARID1A in the mouse endometrial epithelium is s
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Clinical and genomic crosstalk between glucocorticoid receptor and estrogen receptor a in endometrial cancer [ChIP-seq]
Steroid hormone receptors are simultaneously active in many tissues and capable of altering each other''s function. Estrogen receptor ? (ER) and glucocorticoid receptor (GR) are expressed in the uteru
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Targeting PELP1 reduces endometrial cancer progression via attenuation of ribosomal biogenesis. Targeting PELP1 reduces endometrial cancer progression via attenuation of ribosomal biogenesis
We examined the mechanisms by which SMIP34 regulates EEC progression. EEC cells (HEC-1-A) were treated with either vehicle or SMIP34 20µM for 24 hours, and total RNA was isolated for RNA-seq analysis.
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Adenylosuccinate lyase (ADSL) enhances endometrial cancer aggressiveness via increasing killer cell lectin like receptor C3 expression by fumarate
Although ADSL is an enzyme that is involved in de novo purine synthesis, it was reported that ADSL knockdown did not result in decreases in adenine nucleotides (AMP, ADP, and ATP) or GTP. Then, we hyp
NIAID Data Ecosystem30
