Nucleotide variants and their location in canine Pkd1 sequence.

1The position of each variant as the number of nucleotide residues from the 5′ end of the UTR, intron or exon.2Expected nucleotide residues based on the sequence available in the public databases. These nucleotides are considered as normal alleles, as they are not likely to cause the disease (refer to discussion). Where two nucleotides are recorded, there were two nucleotide variants reported for the relevant position in different databases.3NCBI Assay ID available at Single Nucleotide Polymorphism database (dbSNP).4Del; Deletion of 59 bp.5Mutation segregating with BTPKD. G is the wild type allele, and A the mutant allele.6Predicted haplotypes observed in the dogs (the nucleotide in bold indicates the BTPKD SNP):Haplotype 1: 31A-C-A-G-G-G-10C-G-G-G-T-G-GGG-G-Del-11C-C-C-T-G-C-G-T-T-G-C-T-G-10C-G-T-T-T-T-7C-C-G.haplotype 2: 22A-C-A-G-G-A-11C-G-G-G-T-G-GGG-G-Del-13C-C-C-T-G-C-G-T-T-G-C-T-G-11C-G-T-T-T-T-7C-C-G.Haplotype 3: 22A-C-A-G-T-A-11C-G-G-G-T-G-GGG-G-Del-13C-C-C-T-G-C-G-T-T-G-C-T-G-11C-G-T-T-T-T-7C-C-G.Haplotype 4: 22A-T-G-G-G-A-11C-A-A-A-T-A-GGG-G-Del-13C-G-C-C-G-C-G-C-C-A-C-T-A-11C-G-C-C-T-C-6C-C-A.Haplotype 5: 31A-C-A-G-G-G-10C-G-G-G-T-G-GGG-G-Del-11C-C-C-T-G-C-G-T-T-G-C-T-G-10C-A-T-T-T-T-7C-C-G.7Hap; Haplotype.