Cerebral perfusion and cognitive decline in type 2 diabetes

This dataset was collected as part of a study to explore vasoregulation and blood flow in patients with type 2 Diabetes mellitus. It comprises cerebral blood, autonomic functions, laboratory and gait variables in 70 patients with type 2 DM and 70 healthy controls (50-85 years old). Diabetes mellitus is a prevalent, costly condition with high morbidity and mortality that affects nearly 6.3% of the population in the United States. Diabetes mellitus alters the permeability of the blood-brain barrier, thus affecting regional metabolism and microcirculatory regulation. Predictors of cerebrovascular complications of diabetes that are evidence-based on cerebral blood flow, MRI imaging, and cognitive testing are lacking.

Blood flow velocities were measured in the anterior and middle cerebral arteries using transcranial Doppler ultrasound. Cerebral vasoregulation was evaluated by comparing blood flow velocity responses during hypocapnia and hypercapnia, Valsalva maneuver, head-up tilt and sit-to-stand test using simultaneous recordings of cardiovascular variables, blood flow velocity in the anterior and middle cerebral artery using transcranial Doppler and respiratory variables. We applied continuous arterial spin labeling at 3 Tesla MRI to evaluate regional distribution of cerebral blood flow and vasomotor reactivity to CO2. Cognitive and executive functions were assessed via a battery of psychometric measures. Gait and balance were characterized from dynamics of foot pressure distribution and center of pressure displacement.

本数据集系为研究2型糖尿病患者的血管调节及血流状况而收集，包含70例2型糖尿病患者及其70名健康对照者的脑部血流、自主神经功能、实验室及步态变量。糖尿病是一种普遍存在、代价高昂且死亡率高的疾病，其发病率几乎占美国人口的6.3%。糖尿病可改变血脑屏障的通透性，从而影响局部代谢和微循环调节。目前尚缺乏基于脑血流、MRI成像及认知测试的糖尿病脑血管并发症预测指标。通过经颅多普勒超声测量前交通动脉和中交通动脉的血流速度。通过比较低碳酸血症和低碳酸血症期间、Valsalva动作、头部抬高倾斜和坐立测试时的血流速度反应，以及心血管变量、前交通动脉和中交通动脉血流速度和呼吸变量的同步记录，评估脑部血管调节。我们应用3特斯拉连续动脉自旋标记MRI技术，以评估脑部血流区域分布及对二氧化碳的血管运动反应。通过一系列心理测量方法评估认知和执行功能。通过足底压力分布和压力中心位移的动力学特征，描述步态和平衡。