Wnt/beta-catenin signaling in leukemia
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The Wnt/Beta-catenin pathway mediates the transcription of proteins important for maintenance and growth of hematopoietic stem cells. The inhibition of Wnt leads to protein degradation through Beta-Catenin activation by the Axin/APC/CK1/GSK3B protein complex. This pathway is based on figure 5 from Misaghian et al. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3658 CPTAC Assay Portal]
Wnt/Beta-catenin通路调控着对造血干细胞维持与生长至关重要的蛋白质的转录。Wnt信号的抑制通过Axin/APC/CK1/GSK3B蛋白复合物激活Beta-Catenin，进而导致蛋白质的降解。此通路依据Misaghian等人在图5中的研究构建。该通路上的蛋白质具有通过[CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3658)提供的靶向检测方法。
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