Pharmacodynamic effects of GLP-1 agonist liraglutide in adolescent, prediabetic pigs. Sus scrofa

GLP-1 agonists are potent glucose-lowering agents, however, their effect on adolescent organisms needs to be clarified Overall design: Transgenic pigs expressing a dominant-negative GLP receptor randomly assigned for a 90 day treatment trial with liraglutide (0.6-1.8 mg per day)/placebo