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Zinc finger nuclease (ZFN) indels in human, mouse, synthetic Targeted Loci

NIAID Data Ecosystem2026-03-07 收录

锌指核酸酶基因编辑

靶向基因组工程

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA179355 数据链接链接失效反馈

官方服务：

资源简介：

Activity of ZFNs created by Extended Modular Assembly on targets in human and mouse cells.

应用场景：

创建时间：

2012-11-12

锌指核酸酶基因编辑

斑马鱼基因敲除

The Zebrafish is becoming a popular model organism for developmental biology and human disease. This increasing popularity has resulted in a demand for reverse genetics, which has traditionally been n

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Homo sapiens Targeted Locus (Loci)

细胞基因编辑

靶向基因组工程

Homology-driven Genome Editing in human T Cells

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Efficient Immunoglobulin Gene Disruption and Targeted Replacement in Rabbit Using Zinc Finger Nucleases

锌指核酸酶基因编辑

治疗性抗体

Rabbits are widely used in biomedical research, yet techniques for their precise genetic modification are lacking. We demonstrate that zinc finger nucleases (ZFNs) introduced into fertilized oocytes c

NIAID Data Ecosystem10

Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases

HIV基因治疗

锌指核酸酶基因编辑

HIV-1 entry requires the cell surface expression of CD4 and either the CCR5 or CXCR4 coreceptors on host cells. Individuals homozygous for the ccr5Δ32 polymorphism do not express CCR5 and are protecte

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p53 Gene Repair with Zinc Finger Nucleases Optimised by Yeast 1-Hybrid and Validated by Solexa Sequencing

p53

锌指核酸酶基因编辑

The tumor suppressor gene p53 is mutated or deleted in over 50% of human tumors. As functional p53 plays a pivotal role in protecting against cancer development, several strategies for restoring wild-

NIAID Data Ecosystem50

Zinc finger nuclease (ZFN) indels in human, mouse, synthetic Targeted Loci

资源简介：

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