Table_1_Insights from comparison of the clinical presentation and outcomes of patients hospitalized with COVID-19 in an Italian internal medicine ward during first and third wave.DOCX

BackgroundThe reasons of variability of clinical presentation of coronavirus disease-19 (COVID-19) across different pandemic waves are not fully understood, and may include individual risk profile, SARS-CoV-2 lineage and seasonal variations of viral spread. The objective of this retrospective study was to compare the characteristics and outcomes of patients admitted with confirmed coronavirus disease-19 (COVID-19) in the same season during the first (March 2020) and the third pandemic wave (March 2021, dominance of SARS-CoV-2 B.1.1.7 lineage) in an internal medicine ward of a large teaching hospital in Italy.Materials and methodsData of 769 unvaccinated patients (399 from the first and 370 from the third wave) were collected from clinical records, including symptom type and duration, extension of lung abnormalities on chest computed tomography (CT) and PaO2/FiO2 ratio on admission arterial blood gas analysis.ResultsThird wave patients were in average younger (median 65, interquartile range [IQR] 55–75, vs. 72, IQR 61–81 years old, p

背景：新型冠状病毒肺炎（COVID-19）在不同疫情波次中临床表现的变异性原因尚未完全明了，可能涉及个体风险特征、SARS-CoV-2谱系以及病毒传播的季节性变化。本回顾性研究的目的是比较意大利一所大型教学医院内科病房在第一波（2020年3月）和第三波疫情（2021年3月，SARS-CoV-2 B.1.1.7谱系占主导地位）期间，同一季节确诊的COVID-19患者的特征和预后。材料与方法：收集了769名未接种疫苗的患者（第一波399名，第三波370名）的临床数据，包括症状类型及持续时间、胸部计算机断层扫描（CT）上肺病变的范围以及入院动脉血气分析中的PaO2/FiO2比值。结果：第三波患者的平均年龄较轻（中位数65岁，四分位距[55-75]，与第一波相比，中位数为72岁，四分位距为[61-81]岁，p值...）