Two Co(II)-based coordination polymers: structural diversity and treatment effect on children low transit constipation by regulating neurotransmitter release
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https://tandf.figshare.com/articles/dataset/Two_Co_II_-based_coordination_polymers_structural_diversity_and_treatment_effect_on_children_low_transit_constipation_by_regulating_neurotransmitter_release/11902248
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Two new mixed-ligand coordination polymers with the chemical formulae of [Co(3mad)(dpa)]<sub>n</sub> (<b>1</b>, 3mad = 3-methyladipate, dpa = 4,4′-dipyridylamine) and [Co(33dmg)(dpa)]<sub>n</sub> (<b>2</b>, 33dmg = 3,3-dimethylglutarate) have been successfully synthesized by the hydrothermal reaction of the Co(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O, methyl-substituted aliphatic dicarboxylic acid, and the hydrogen-bonding capable 4,4′-dipyridylamine (dpa) ligand. Furthermore, the treatment activity of compounds <b>1</b> and <b>2</b> against low transit constipation (STC) was evaluated <i>in vivo</i>. Firstly, the ELISA detection was conducted for the neurotransmitter measurement, such as acetylcholine and serotonin. Then, the intestinal transmission function was tested to reflect the treatment effect of compounds <b>1</b> and <b>2</b> <i>in vivo</i>.
提供机构：
Taylor & Francis
创建时间：
2020-02-26
