CNS HAND Study data for cognitive aging analysis

The CNS HAND study was primarily conducted among 254 people living with HIV (PLHIV) and 72 HIV-negative persons from a primary care clinic in Sydney, Australia named Holdsworth House General Practice to assess the burden of HIV-associated neurocognitive disorder (HAND) among PLHIV and to validate the CogState computerized cognitive screening tool for the diagnosis of HAND. The study took place between October 2011 and December 2013. Exclusion criteria at the entry of the study was alcohol or substance intoxication. An analysis was conducted using the data from this study to determine premature cognitive aging among PLHIV. This deidentified individual participant dataset was used for this analysis and is made publicly available for other researchers.

本研究为中枢神经系统人类免疫缺陷病毒相关神经认知障碍（HIV-associated neurocognitive disorder, HAND）研究，主要招募了来自澳大利亚悉尼霍兹沃思全科诊所（Holdsworth House General Practice，一家初级保健诊所）的254名HIV感染者（People Living with HIV, PLHIV）与72名HIV阴性个体，旨在评估HIV感染者群体中HAND的疾病负担，并验证用于诊断HAND的CogState计算机化认知筛查工具。本研究于2011年10月至2013年12月期间开展。研究入组时的排除标准为酒精或物质中毒。后续基于本研究的数据开展了一项分析，以探究HIV感染者的过早认知衰老情况。本次分析使用了该研究的去标识化个体参与者数据集，且该数据集已向其他研究人员公开共享。