Figure S1 - Retinal Degeneration Progression Changes Lentiviral Vector Cell Targeting in the Retina

Gliosis occurs during retinal degeneration of the Rd1 mouse retina. The mouse bears a mutation in the Pde6b gene leading to phototransduction inhibition and photoreceptor loss. At P12, GFAP (red) expression is mainly detected in the inner part of the retina. At p15, the gliosis increases when several layers of photoreceptors were already lost (compare the ONL size with WT retina). Magnification: 200x. (PDF)