Effect of a dendritic cells derived extracellular vesicle as therapeutic vaccine platform to induce neuroprotective immunity for spinal cord injury

we designed a nano-vaccine platform using dendritic cell-derived small extracellular vesicles (DsEVs) as carriers for MBP87-99A91(A91-DsEVs) to induce a neuroprotective immunity for spinal cord injury. We performed gene expression profilling analysis using data obtained from RNA-seq of A91-DsEVs treatment group and control group (PBS group) at 3 time points, there were 4 samples in A91-DsEVs treatment group in each time point, and 3 samples in PBS group at each time point