In eukaryotic cells, the highly conserved FACT (FAcilitates Chromatin Transcription) complex plays important roles in several chromatin-based processes including transcription initiation and elongatio
Our studies suggest that BRD4 plays a critical role in muscle fiber-type regulation, yet the molecular mechanisms by which BRD4 cooperates with MEF2 to control muscle gene expression remain incomplete
Transcription activity is tightly correlated with a stereotypical suite of chromatin features and modifications, but how/if these are interpreted by transcriptional machinery remains poorly understood
Eukaryotic nucleosomes consists of an (H3-H4)2 tetramer and two H2A-H2B dimers, around which 147 bp of DNA are wrapped in 1.7 left-handed helical turns. During chromatin assembly, the (H3-H4)2 tetrame
Kabuki Syndrome (KS) is a multisystemic rare disorder, characterized by growth delay, distinctive facial features, intellectual disability, and rarely autism spectrum disorder. This condition is mostl
