Concise Synthesis of 3,7-Dioxa-9-aza-bicyclo[3,3,1]-nonane
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https://figshare.com/articles/dataset/Concise_Synthesis_of_3_7_Dioxa_9_aza_bicyclo_3_3_1_nonane/3245377
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资源简介：
The basicity of an amine has a great impact on physicochemical properties and pharmacokinetics. To attenuate the
basicity of morpholine, a bicyclic amine was designed and
synthesized with the introduction of an additional β-oxygen.
A transannular cyclization and reduction of a bridgehead
α-chloro amine functionality produces the topographically
unusual amine (pKa = 6.7) in good yield.
创建时间：
2016-05-05
