3D Multi-Scale Phase Contrast Imaging of CoViD-19 Human Skin Biopsies

Concomitantly to the first pandemic wave of Covid19, an unexpected high number of chilblains cases of the toes have been reported, without a clear demonstrated relationship between both phenomena. Histological studies are limited to 2D at a given resolution, whilst, thanks to its 3D high resolution and very high contrast capabilities in soft tissue, Synchrotron micro and nano X-ray phase contrast imaging might help in understanding the link between these two phenomena. The aim of this continuation proposal is to perform a complementary multi-scale three-dimensional PCI analysis of human skin samples from COVID19 positive and negative chilblain toes patients biopsied during the first pandemic wave to strengthen our results and to perform a semi-quantitative analysis of the data.