Copper-Catalyzed Three-Component Cyano­trifluoro­methyla­tion/Azido­trifluoro­methyla­tion and Carbo­cycli­zation of 1,6-Enynes

A novel three-component strategy for the cyano­trifluoro­methyla­tion/azido­trifluoro­methyla­tion and carbocyclization of 1,6-enynes is developed. The reaction proceeds smoothly under a moderate temperature by using a copper catalyst, which provides a rapid and concise access to addition–carbocyclization products. Furthermore, the products obtained can be useful building blocks in discoveries of lead compounds and other biologically active CF3-containing heterocycles.