Thrombus proteomics reveals new candidate biomarkers of stroke etiology

In this study, we have profiled the protein content of intravascular thrombotic material from stroke patients in the acute stage by quantitative proteomics. To this end, thrombotic material obtained by intra-arterial thrombolysis from stoke patients with different etiologies by TOAST classification (atherotrombotic and cardioembolic) was processed and further underwent proteomics analysis. As a result, we report a number of novel protein biomarkers that may help in differentiating atherotrombotic from cardioembolic stroke