Aminoglycoside tolerance in Vibrio cholerae engages translational reprogrammi...

Tgt is the enzyme modifying the guanine (G) in tRNAs with GUN anticodon to queuosine (Q). tgt is required for optimal growth of Vibrio cholerae in the presence of sub-lethal...Tgt是一类负责将携带GUN反密码子的转运RNA（transfer RNA，tRNA）上的鸟嘌呤（guanine，G）修饰为Q核苷（queuosine，Q）的酶。在亚致死[原文后续内容截断]的环境条件下，Tgt对于霍乱弧菌（Vibrio cholerae）的最优生长具有不可或缺的作用。