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831 brain tropic exosomes
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2015-08-06
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Non-human primate blood-brain barrier and in vitro brain endothelium: from transcriptome to the establishment of a new model
The blood-brain barrier (BBB) represents a major challenge when developing central nervous system (CNS)-active therapeutics. The non-human primate (NHP)-brain endothelium constitutes an essential alte
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Development of Novel Zn2+ Loaded Nanoparticles Designed for Cell-Type Targeted Drug Release in CNS Neurons: In Vitro Evidences
Intact synaptic function and plasticity are fundamental prerequisites to a healthy brain. Therefore, synaptic proteins are one of the major targets for drugs used as neuro-chemical therapeutics. Unfor
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Atoxic Derivative of Botulinum Neurotoxin A as a Prototype Molecular Vehicle for Targeted Delivery to the Neuronal Cytoplasm
We have previously described genetic constructs and expression systems that enable facile production of recombinant derivatives of botulinum neurotoxins (BoNTs) that retain the structural and traffick
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Blood brain barrier (BBB) permeability of injectable (S)-roscovitine.
(S)-roscovitine permeability to the BBB solubilized in 4% HPbCD was examined after IV administration of the compound to healthy adult rats. (S)-roscovitine was administered at 2 doses (20 and 30 mg/kg
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