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Ruthenium- and Copper-Catalyzed Enantioselective Propargylic Alkylation of Propargylic Alcohols with β-Keto Phosphonates

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NIAID Data Ecosystem2026-03-07 收录
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The enantioselective propargylic alkylation of propargylic alcohols with β-keto phosphonates in the presence of a thiolate-bridged diruthenium complex and a copper complex as cocatalysts gives the corresponding propargylic alkylated products in excellent yields with high diastereo- and enantioselectivities (up to 97% ee).

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2012-04-23
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