16s rRNA of gut microbiome in PBC and pSS

This study aimed to analyze gut microbiome similarities and differences between primary biliary cholangitis (PBC) and primary Sjögren’s syndrome (pSS), exploring potential associations with disease pathogenesis. High-throughput sequencing of the 16S rRNA gene was performed on feacal samples from 100 subjects (PBC: 38, pSS: 42, HC: 20) to compare composition, diversity, and key microbial markers, examining associations with clinical indicators.