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Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo

ChEBI2015-08-24 更新2026-07-12 收录

p53转录调控

B细胞免疫应答

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-71180 数据链接链接失效反馈

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资源简介：

Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo

应用场景：

创建时间：

2015-08-24

B细胞免疫应答

基因缺陷模型

Analyze kinetics, cell composition and proliferation of germinal center B cells in wt vs Ung-/- vs Aicda-/- vs Ung-/- Aicda-/- mice after immunization with model antigens.

NIAID Data Ecosystem80

Raw data for Fig 4 in pzfx format.

补体系统免疫

B细胞免疫应答

Francisella tularensis (Ft), a Gram-negative bacterium that causes tularemia, possesses a non-inflammatory atypical LPS (LPSFt) that is highly immunogenic through unknown mechanism. We previously show

Figshare2025-12-17 更新50

TET enzymes augment AID expression via 5hmC modifications at the Aicda superenhancer [H3K27ac_ChIP-seq]. TET enzymes augment AID expression via 5hmC modifications at the Aicda superenhancer [H3K27ac_ChIP-seq]

5hmC表观遗传

B细胞免疫应答

TET enzymes are dioxygenases that promote DNA demethylation by oxidizing the methyl group of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Here we report a close correspondence between 5hm

NIAID Data Ecosystem50

Global genomic profiling of p53-regulated genes. Mus musculus

p53转录调控

DNA损伤响应

p53 is a critical tumor suppressor and works as a stress-induced transcription factor to induce target genes mediating apoptosis, cell cycle arrest and senescence or other responses. To gain new insig

NIAID Data Ecosystem70

A large intergenic non-coding RNA induced by p53 mediates global gene repression in the p53 transcriptional response. Mus musculus

p53转录调控

非编码RNA功能

Recently, more than a thousand large intergenic non-coding RNAs (lincRNAs) have been reported. These RNAs are evolutionarily conserved in mammalian genomes and thus presumably function in diverse biol

NIAID Data Ecosystem50

Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo

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