Extreme model exploration of a multi-scale simulation of tumor growth

The dataset comprises the output of several simulations of a model of tumor growth with different parameter values. The model is a multi-scale agent-based model of a tumor spheroid that is treated with periodic pulses of the cytokine tumor necrosis factor (TNF). The multi-scale model simulates processes including i) the diffusion, uptake, and secretion of molecular entities such as oxygen, or TNF; ii) the mechanical interaction between cells; and iii) cellular processes including cell life cycle, cell death models, signal transduction.

The multi-scale model was implemented and simulated using the PhysiBoSS framework (Letort et al. 2019). The dataset corresponds to different simulations trajectories obtained for alternative parameter values. The parameter explored are: i) the decay rate of the TNF after it binds the cell; ii) the TNF binding rate; and iii) the TNF secretion rate by NFkB activated cells.

The dataset includes 48 different combinations of parameters. Each simulation is stored in a folder instance_[0-9]+ which includes the PhysiBoSS standard output files (https://github.com/gletort/PhysiBoSS/wiki). The root folder also includes other settings, logs, and outputs as well as the binary used to run the simulation.