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Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration

NIAID Data Ecosystem2026-05-01 收录

神经退行性疾病基因

DNA损伤与3D基因组结构

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE227445 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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创建时间：

2023-10-02

神经退行性疾病基因

拷贝数变异分析

The possible role of somatic copy number variations (CNVs) in Alzheimer's disease (AD) aetiology has been controversial. Although cytogenetic studies suggested increased CNV loads in AD brains, a rece

NIAID Data Ecosystem110

Expression data from SIRT6 knockout, young WT and old WT mice brains. Expression data from SIRT6 knockout, young WT and old WT mice brains

脑衰老转录组学

神经退行性疾病基因

Brain-specific SIRT6-KO mice present increased DNA damage, learning impairments, and neurodegenerative phenotypes, placing SIRT6 as a key protein in preventing neurodegeneration. In the aging brain, S

NIAID Data Ecosystem80

Cross-species analysis across 450 million years of evolution reveals conservation and divergence of the microglia program (bulk RNA-seq)

小胶质细胞转录组进化

神经退行性疾病基因

Here we characterize microglia transcriptional program across ten species spanning more than 450 million years of evolution. We find that microglia express a conserved core gene program of orthologous

Alliance of Genome Resources30

Sequencing of DNA from MSA brain. MSA brain sequencing

神经退行性疾病基因

单细胞脑组织测序

We have sequenced MSA brain as follows1. Mate pair sequence for one case, substantia nigra and cerebellum2. Exome sequences from 13 cases3. Single cell low coverage WGS, 170 cells passing QC and analy

NIAID Data Ecosystem100

In vivo repair of a protein underlying a neurological disorder by programmable RNA editing

神经退行性疾病基因

RNA靶向

The goal of this study is to determine the effects of targeted RNA editing in the hippocampus of a mouse model of Rett syndrome. Mice containing a patient G>A mutation in Methyl CpG binding Protein 2

NIAID Data Ecosystem80

Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration

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