Use of routine WGS for TB diagnosis in Peru

NIAID Data Ecosystem2026-03-14 收录

结核病诊断

基因组测序应用

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA906938 数据链接链接失效反馈

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资源简介：

Evaluation of the use of Whole Genome Sequencing in theroutine diagnosis of drug-resistant tuberculosis in Peru

创建时间：

2022-11-30

Next-generation metagenome sequencing shows superior diagnostic performance in acid-fast staining sputum smear-negative pulmonary tuberculosis and non-tuberculous mycobacterial pulmonary disease

结核病诊断

基因组测序

In this study, we explored the clinical value of next-generation metagenome sequencing (mNGS) using bronchoalveolar lavage fluid (BALF) samples from patients with acid-fast staining (AFS) sputum smear

NIAID Data Ecosystem50

Characteristics of all patients (n = 468) for whom results of sputum cultures were available from one or more sputum samples.

结核病诊断

痰液分析

aData are number of patients (percent) unless otherwise indicated.bComparison of characteristics of patients with and without TB.cChest radiographs available for 418 patients.

Figshare2015-12-02 更新10

Xpert sputum quality dataset.

结核病诊断

痰液样本质量评估

Complete dataset utilized for data analysis. (CSV)

Figshare2017-07-08 更新10

Quotes illustrating themes.

结核病诊断

医疗技术评估

Challenges in diagnosing drug-resistant tuberculosis (DR-TB) contribute to a diagnostic gap. Design-locked Targeted Sequencing (TS) assays have the potential to improve DR-TB diagnosis and management.

Figshare2025-06-12 更新20

Performance of scoring system among smear-negative patients in comparison to checklist-based diagnosis (n = 47 with PTB and 335 without PTB).

结核病诊断

临床诊断评分系统

*This judgment (consistent or not consistent with active TB) was the interpretation of the reader recorded on completion of the CRRS read. in the appropriate block on the CRRS form. (see online reposi

Figshare2015-12-02 更新10

Use of routine WGS for TB diagnosis in Peru

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