Data from: Rapid molecular evolution across amniotes of the IIS/TOR network

Comparative analyses of central molecular networks uncover variation that
can be targeted by biomedical research to develop insights and
interventions into disease. The insulin/insulin-like signaling and target
of rapamycin (IIS/TOR) molecular network regulates metabolism, growth, and
aging. With the development of new molecular resources for reptiles, we
show that genes in IIS/TOR are rapidly evolving within amniotes (mammals
and reptiles, including birds). Additionally, we find evidence of natural
selection that diversified the hormone-receptor binding relationships that
initiate IIS/TOR signaling. Our results uncover substantial variation in
the IIS/TOR network within and among amniotes and provide a critical step
to unlocking information on vertebrate patterns of genetic regulation of
metabolism, modes of reproduction, and rates of aging.