Supplementary Material for: A Prospective Study of the Use of Fetal Intelligent Navigation Echocardiography (FINE) to Obtain Standard Fetal Echocardiography Views

Objective: To evaluate the performance of Fetal Intelligent Navigation Echocardiography (FINE) applied to spatiotemporal image correlation (STIC) volume datasets of the normal fetal heart in generating standard fetal echocardiography views. Methods: In this prospective cohort study of patients with normal fetal hearts (19-30 gestational weeks), one or more STIC volume datasets were obtained of the apical four-chamber view. Each STIC volume successfully obtained was evaluated by STICLoop™ to determine its appropriateness before applying the FINE method. Visualization rates for standard fetal echocardiography views using diagnostic planes and/or Virtual Intelligent Sonographer Assistance (VIS-Assistance®) were calculated. Results: One or more STIC volumes (total n = 463) were obtained from 246 patients. A single STIC volume per patient was analyzed using the FINE method. In normal cases, FINE was able to generate nine fetal echocardiography views using: (1) diagnostic planes in 76-100% of the cases, (2) VIS-Assistance® in 96-100% of the cases, and (3) a combination of diagnostic planes and/or VIS-Assistance® in 96-100% of the cases. Conclusion: FINE applied to STIC volumes can successfully generate nine standard fetal echocardiography views in 96-100% of cases in the 2nd and 3rd trimesters. This suggests that the technology can be used as a method of screening for congenital heart disease.

研究目的：评估胎儿智能导航超声心动图（Fetal Intelligent Navigation Echocardiography, FINE）应用于正常胎儿心脏的时空图像关联（spatiotemporal image correlation, STIC）容积数据集时，生成标准胎儿超声心动图切面的性能。
研究方法：本研究针对孕周19~30周的正常胎儿心脏患者开展前瞻性队列研究，采集至少1幅心尖四腔心切面的STIC容积数据集。每幅成功获取的STIC容积数据在应用FINE方法前，均通过STICLoop™进行适用性评估。计算采用诊断切面和/或虚拟超声医师智能辅助系统（Virtual Intelligent Sonographer Assistance, VIS-Assistance®）时，标准胎儿超声心动图切面的可视化成功率。
研究结果：共从246例患者中获取至少1幅STIC容积数据（总计463幅）。每例患者仅选取1幅STIC容积数据用于FINE方法分析。在正常胎儿心脏病例中，FINE可通过以下三种方式生成9种标准胎儿超声心动图切面：（1）仅采用诊断切面，成功率为76%~100%；（2）仅采用虚拟超声医师智能辅助系统，成功率为96%~100%；（3）联合使用诊断切面与/或虚拟超声医师智能辅助系统，成功率为96%~100%。
研究结论：将FINE应用于STIC容积数据集时，可在妊娠中晚期96%~100%的病例中成功生成9种标准胎儿超声心动图切面。这表明该技术可作为先天性心脏病筛查手段。