Data for: Getting over it? A proteomic analysis of mechanisms driving multigenerational acclimation to organic ultraviolet filters in Daphnia magna

Organic ultraviolet filters (UVFs) such as avobenzone, octocrylene, and
oxybenzone are contaminants of concern due to their widespread occurrence
in aquatic environments. Previous research has demonstrated that these
UVFs are toxic to aquatic invertebrates over single-generation exposures;
however, data regarding long-term outcomes across generations of exposure
are lacking. This study sought to identify the mechanisms of toxicity to
novel UVF exposure in D. magna and subsequent responses across 5
generations of continuous exposure by quantifying proteomic changes at the
end of the F0, F1, and F3 generations. A parallel study observed toxicity
to novel UVF exposure (> 40 % mortality, 46 % decreased
reproduction); however, toxic effects were absent after 3 generations of
continuous exposure. Impaired metabolism and immune response processes
were observed in the F0 generation, with decreased abundance in >
80% of altered proteins in octocrylene and oxybenzone exposures.
Impairment of these processes was gradually reversed over subsequent
generations, with > 60 % of altered proteins demonstrating
increased abundance by the F3 generation. An increase in chitin production
that could reduce membrane permeability to xenobiotics and pathogens,
along with subtle changes in metabolic processes may allow exposed
populations to negate many of the negative effects associated with UVF
exposure. These results offer mechanistic insights into the gradual
acclimation of continuously exposed D. magna populations that have been
observed in response to a variety of contaminants and further serve to
highlight the importance of utilizing a long-term approach for studies
seeking to model contamination risks in wild populations.