Cleaned dataset for PubChem AID 720725: qHTS assay of glucocorticoid receptor (GR) antagonists

This dataset is derived from PubChem BioAssay AID 720725, titled "qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway". The original assay is part of the Tox21 program and evaluates inhibition of glucocorticoid receptor (GR) signaling using a beta-lactamase reporter assay in mammalian cells expressing a GR-responsive reporter system. Original dataset statistics: - Tested compounds: 8,099 - Active (antagonists): 384 - Inactive: 6,178 Data preprocessing: - Removed duplicate entries based on compound identifiers. - Resolved conflicting labels by excluding compounds with inconsistent activity annotations. Final cleaned dataset: - Total compounds: 6,185 - Positive (antagonists): 294 - Negative (inactive): 5,891