S7 Table -

Differential expression analysis of B. glabrata FReD genes between RES-exposed and SUS-exposed to S. mansoni at different time points Notes: 1. Value in cells represents the value of log2(fold change) or log2(FC). Any up-regulated gene with log2(FC) ≥1 is highlighted in red, and any down-regulated gene with log2(FC) ≤-1 is highlighted in blue. 2. “0.5dpe, 2dpe, 8dpe, 40dpe” represent the 4 sampling time points. They include time-matched unexposed controls and exposed snails for valid comparisons. 3. ns: no significant expression difference detected. Gene with PPDE ≥0.95 and FC ≥2 in EBSeq analysis is considered to be differentially expressed in this study. 4. In the column of “Type of FReD”, B. glabrata FReD proteins were considered “partial” based on the criteria set in this study. “1-IgSF FREP” and “2-IgSF FREP” represent numbers of IgSF domains in a particular FREP. 5. “Best hit to published FREP” in the last column represents the best hit of the protein against published B. glabrata FREP sequences from available sources [30,32–34]. Any protein sequence identity ≥90% is considered as the same FREP; identity 85~90% is considered as the corresponding FREP “-like”; identity <85% is not assigned to any published FREP. Several FREPs were highlighted in yellow to emphasize in this study. 6. In the differential expression analysis, SUS unexposed snails were set as baseline for the corresponding time-matched RES unexposed snails at constitutive level; RES unexposed snails were used as baseline for the corresponding time-matched RES snails exposed to S. mansoni; similarly, SUS unexposed snails were used as baseline for the corresponding time-matched SUS snails exposed to S. mansoni.
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