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Targeting Ewing sarcoma cells via small molecule YK-4-279 treatment and downregulation of DHX9 helicase

NIAID Data Ecosystem2026-05-02 收录

肉瘤靶向治疗

小分子药物机制

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301794 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2025-07-08

肉瘤靶向治疗

FACT复合物

EWS/ETS fusion transcription factors, most commonly EWSR1-FLI1, drive initiation and progression of Ewing sarcoma (EwS), a highly aggressive childhood cancer of bone and soft tissues. Even though dire

NIAID Data Ecosystem100

Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma [CUT&RUN, 2]. Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma [CUT&RUN, 2]

肉瘤靶向治疗

表观遗传药物靶点

Chimeric transcription factors drive lineage-specific oncogenesis but are notoriously difficult to target. Alveolar rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue sarcoma transformed by

NIAID Data Ecosystem80

Supplemental Table 1 from A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma

肉瘤靶向治疗

IGF1R抑制剂研究

Related to Figure 1

NIAID Data Ecosystem30

A SIX1/EYA2 small molecule inhibitor disrupts EMT and metastasis

乳腺癌转移

小分子药物机制

This study identified a novel compound reverses SIX1-mediated EMT and metastasis in breast cancer Overall design: RNA-seq was used to identify transcriptional signature that is influenced by SIX1 over

NIAID Data Ecosystem90

Small Molecule Survivin Inhibitor YM155 Displays Potent Activity Against Human Osteosarcoma Cells

肉瘤靶向治疗

小分子抑制剂

Survivin is an important oncogenic protein expressed highly in osteosarcoma. Here, we have shown that small molecule inhibitor YM155 potently suppressed survivin expression, inhibited cell growth, and

NIAID Data Ecosystem40

Targeting Ewing sarcoma cells via small molecule YK-4-279 treatment and downregulation of DHX9 helicase

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