LC-MS analysis of faecal extracts obtained during colorectal cancer resectional surgery

A prospective observational pilot study from right-sided colorectal cancer (RCRC) patients was performed at Imperial College London NHS Trust, UK. Treatment naïve patients undergoing elective resectional surgery for primary RCRCs were recruited. Fresh intra-luminal fecal samples were obtained at three anatomical sites: 5 cm pre-, tumour, and 5 cm post-tumour. Samples were analysed by liquid chromatography-mass spectrometry.  [1]

[1] Petra Paizs, Duncan Roberts, Nathan Danckert, James Lewis, Maria Sani, Marta Jamroziak, Robert Goldin, Julian Marchesi, Lauren Ford, James Alexander, Zoltan Takats, James Kinross. Gut microbial co-metabolism influences the tumor microenvironment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3056.