Gene expression profile of chronically activated CD4+ T cells from cancer patients

CD4+ T cells as mediators of antitumor responses are beginning to be appreciated. Our team demonstrated that chronically activated CD4+ T cells (chCD4+ T cells) were expanded in the blood of cancer patients and their expansion is correlated with tumor regression. Here we characterized the gene expression profile of this population with therapeutic potential. Conventional CD4+ T cells (Tconv cells=CD3+CD4+CD127+CD25±) and chronically activated CD4+ T cells (chCD4 T cells=CD3+CD4+CD127-CD25-) were sorted from the blood of healthy donor or patients with metastatic uveal melanoma.