Role of mTOR in regulating the extra cellular matrix

NIAID Data Ecosystem2026-03-10 收录

肺纤维化机制

细胞外基质调控

数据链接：

https://www.omicsdi.org/dataset/pride/PXD010164 数据链接链接失效反馈

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资源简介：

Explored the potential role of mTOR in regulating the extra cellular matrix of TGF-b1-stimulated IPF fibroblasts grown under macromolecular crowding conditions in the presence of either CZ415 or rapamycin

创建时间：

2018-11-04

Transcriptomic Signature-Guided Depletion of Intermediate Alveolar Epithelial Cells Ameliorates Pulmonary Fibrosis in Mice

肺纤维化机制

单细胞转录组学

scRNA-seq was used to profile transitional AT2 cells in bleomycin-injured mouse lungs. Using an RNA-sensing strategy, Sprr1a-expressing cells corresponding to Krt8? alveolar differentiation intermedia

NIAID Data Ecosystem60

Standard miRNA-gene interactome of extracellular matrix genes for human trabecular meshwork cells stimulated by TGF-β1.

细胞外基质调控

miRNA-靶基因互作

Standard miRNA-gene interactome of extracellular matrix genes for human trabecular meshwork cells stimulated by TGF-β1.

Figshare2025-01-30 更新40

Phylotranscriptomic analysis uncovers a wealth of tissue inhibitor of metalloproteinases variants in echinoderms

分子系统学

细胞外基质调控

Tissue inhibitors of metalloproteinases (TIMPs) help regulate the extracellular matrix (ECM) in animals, mostly by inhibiting matrix metalloproteinases (MMPs). They are important activators of mutable

NIAID Data Ecosystem30

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. Homo sapiens

肺纤维化机制

基质刚度响应

We tested the hypothesis that increasing matrix stiffness on which normal human lung fibroblasts are grown promotes the expression of a fibrogenic cellular transcriptomic program. Keywords: Human lung

NIAID Data Ecosystem40

Gene expression profiling of CD11c+ or CD11b+ cells from bronchoalveolar lavage fluid was conducted in a bleomycin-induced pulmonary fibrosis model following GW5074 treatment or in Clec7a KO mice

肺纤维化机制

单细胞RNA测序

To investigate the role of the Dectin-1 signaling pathway in the development of pulmonary fibrosis, we established a BLM-induced pulmonary fibrosis model using WT mice, Dectin-1-deficient mice (Clec7a

NIAID Data Ecosystem30

Role of mTOR in regulating the extra cellular matrix

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