Master aceQTLs.

(i)Sum of linkage posterior probabilities across all target nucleosomes.(ii)Based on annotations of target genes and previous eQTL studies [38], [47].(iii)Nae/Na, where Nae is the number of nucleosomes targeted by this master-aceQTL, that are located within 10 Kb of a gene identified as an eQTL target of the same regulatory region; and Na is the total number of nucleosomes targeted by this master-aceQTL.(iv)Based on the fraction of nucleosomes matching expression targets: ‘aceQTL only’: less than 25%, ‘also eQTL’: more than 75%, ‘partial’: in between. In some cases, ‘partial’ or ‘aceQTL only’ could be seen despite the colocalization of a master-eQTL because acetylation and expression control did not act on the same target loci.(v)Target nucleosomes that were located within 1 Kb of each other were grouped into a single “locus”.