Total Synthesis and Anti-Inflammatory Activity of Tectoridin and Related Isoflavone Glucosides
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https://figshare.com/articles/dataset/Total_Synthesis_and_Anti-Inflammatory_Activity_of_Tectoridin_and_Related_Isoflavone_Glucosides/28104256
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资源简介：
The
first total syntheses of four isoflavone glucosides,
tectoridin
(1), tectoridin A (2), tectorigenin 7-O-β-d-glucopyranosyl-12-O-β-d-glucopyranoside (3), and isotectroigenin
7-O-β-d-glucopyranoside (4), have been accomplished. Key steps in our synthetic approach include
a regioselective halogenation reaction, followed by methanolysis to
introduce the −OCH3 group into isoflavone frameworks
and a PTC-promoted stereoselective glycosidation to establish glycosidic
bonds. The synthesized isoflavone glucosides (1–4) and their corresponding aglycones (32 and 34) were evaluated for anti-inflammatory activity against
nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin-6
(IL-6), and interleukin-1 β (IL-1β) in lipopolysaccharide
(LPS)-induced RAW264.7 cells. Aglycones 32 and 34 exhibited stronger anti-inflammatory activity in
vitro compared to isoflavone glucosides 1–4.
创建时间：
2024-12-28
